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Become part of our team to lead early-stage drug discovery projects focused on retinal disease, utilizing your expertise in neural retina biology and ocular pathology to identify and validate therapeutic targets. At Roche, you are valued for your unique qualities and encouraged to thrive both personally and professionally, as we aim to prevent, stop, and cure diseases and ensure access to healthcare for all generations.

Tasks

  • Utilize and establish advanced in vitro and in vivo models of ocular disease, and leverage patient sample datasets to identify, validate, and characterize novel therapeutic drug targets.
  • Identify and evaluate optimal therapeutic modalities for selected targets.
  • Independently lead and manage drug discovery projects from target initiation through early clinical development stages (up to Phase II readiness).
  • Partner with interdisciplinary teams across pRED, including bioinformatics, safety, and translational medicine, to advance pipeline programs.
  • Initiate and lead external collaboration projects to bolster internal efforts.
  • Manage CRO activities, including project design, timelines, and quality of deliverables.
  • Present research findings at internal decision-making meetings, author high-impact publications in top-tier peer-reviewed journals, and represent Roche at international scientific conferences.
  • Support and coordinate safety, health, and environmental processes in the lab.

Requirements

  • PhD in Biology, Neuroscience, Biochemistry, or a related life sciences discipline.
  • Completed Postdoctoral Fellowship in Vision Research, Neural Retina, Ophthalmology, or a closely related field.
  • Comprehensive knowledge of neural retina biology and mechanisms underlying retinal disease pathogenesis, with a proven track record of conducting experiments using models of ocular angiogenesis, fibrosis, inflammation, or neurodegeneration.
  • Direct hands-on experience in animal handling and/or ocular procedures, OR demonstrated expertise in developing novel 2D/3D model systems, such as organoids or organ-on-a-chip.
  • Experience in cell/tissue culture, -omics technologies, and/or basic bioinformatic tools.
  • Excellent organizational skills, rigorous record-keeping, exceptional oral and written English communication, and a strong collaborative mindset in a fast-paced environment.
  • 2–3 years of additional professional experience in academic or industry drug discovery settings, with a proven track record of leading research projects and cross-functional project teams and a strong publication record in top-tier vision or scientific journals.
  • Established professional network within the global ophthalmology research community.
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Über uns
Roche ist ein international tätiges Schweizer Pharma- und Diagnostikunternehmen mit Sitz in Basel und entwickelt, produziert und vertreibt Medikamente sowie diagnostische Lösungen. Das Unternehmen ist in den Bereichen Pharma und Diagnostik tätig und fokussiert sich auf Forschung und Innovation in verschiedenen Therapiegebieten wie Onkologie, Neurologie und Infektionskrankheiten. Roche ist weltweit aktiv und zählt zu den führenden Unternehmen im Gesundheitsbereich.
Das Team

The Ophthalmology team in Basel focuses on discovering novel therapeutic approaches for major eye diseases, including dry AMD/geographic atrophy, neovascular forms, diabetic retinopathy, and other retinal vascular diseases.

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