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Join us to lead the development of therapeutic siRNA oligonucleotides, focusing on disease-targeted optimisation and clinical development. Drive innovation in drug design strategy and collaborate with cross-functional teams. Ideal for experienced scientists with expertise in siRNA/RNAi design and a strong background in molecular biology or bioinformatics.

Tasks

  • Lead the drug design strategy of oligonucleotides with a strong focus on siRNAs, leveraging computational and empirical approaches for both initial Proof of Concept on novel targets and full-scale lead optimization for clinical development.
  • Guide projects holistically, ensuring early design decisions align with late-stage clinical and manufacturing requirements.
  • Utilize and invent new advanced chemical modification patterns and sequence selection strategies to optimize relevant pharmacological properties of siRNAs.
  • Work in close partnership with AI experts to develop, validate, and apply AI design solutions, providing biological data and domain expertise to enhance machine-learning approaches.
  • Act as the RNAi subject matter expert in collaboration with project teams and disease experts.
  • Design and optimize therapeutic siRNA against various disease targets, working from Target Assessment through Lead Optimization across different disease areas.
  • Integrate deep scientific expertise with high quality execution of discovery programs.

Requirements

  • Ph.D. in Molecular Biology, Bioinformatics, Biochemistry, or a related field with 5+ years of industry experience specifically in siRNA/RNAi therapeutic design.
  • Deep understanding of the RNAi mechanism and profiling of siRNA therapeutics.
  • Proven track record in applying chemical modification patterns of siRNA to enhance therapeutic profile.
  • Familiarity with the interface of biology and data science; comfortable discussing parameters and data features with AI engineers.
  • Hands-on experience with command-line utilities and scripting languages for biological sequence analysis and data management.
  • Ability to communicate complex nucleic acid chemistry to non-experts and integrate feedback from diverse stakeholders.
  • Ability to balance aggressive development timelines with meticulous attention to detail.
  • Excellent communication skills, capable of translating complex scientific concepts into clear, actionable insights for diverse audiences.
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Über uns
Roche ist ein international tätiges Schweizer Pharma- und Diagnostikunternehmen mit Sitz in Basel und entwickelt, produziert und vertreibt Medikamente sowie diagnostische Lösungen. Das Unternehmen ist in den Bereichen Pharma und Diagnostik tätig und fokussiert sich auf Forschung und Innovation in verschiedenen Therapiegebieten wie Onkologie, Neurologie und Infektionskrankheiten. Roche ist weltweit aktiv und zählt zu den führenden Unternehmen im Gesundheitsbereich.
Das Team

In Roche’s Pharmaceutical Research and Early Development organization (pRED), teams are united by the mission to transform science into medicines. The Therapeutic Modalities (TMo) organization is accountable for translating disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines, driving innovation through cross-disciplinary collaboration.

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